Author: Emily K. Mantlo; Natalya Bukreyeva; Junki Maruyama; Slobodan Paessler; Cheng Huang
Title: Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection Document date: 2020_4_5
ID: kb3z3b8f_3
Snippet: Type I interferons (IFN-α/β) have broad spectrum antiviral activities against RNA viruses, which act by inducing 59 an antiviral response across a wide range of cell types and mediating adaptive immune response. Humans 60 produce 13 types of IFN-α and a singular IFN-β (2). Type I IFNs ultimately induces a number of interferon-61 stimulated genes (ISGs) which encode for a variety of antiviral effectors (3). Notably, IFN-ï¢ production leads to.....
Document: Type I interferons (IFN-α/β) have broad spectrum antiviral activities against RNA viruses, which act by inducing 59 an antiviral response across a wide range of cell types and mediating adaptive immune response. Humans 60 produce 13 types of IFN-α and a singular IFN-β (2). Type I IFNs ultimately induces a number of interferon-61 stimulated genes (ISGs) which encode for a variety of antiviral effectors (3). Notably, IFN-ï¢ production leads to 62 a positive feedback loop that further stimulates the expression of many of the IFN-α genes (4). Clinically, Type The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.02.022764 doi: bioRxiv preprint Vero cells (2x10 4 /well) were seeded into 48-well plates for 24 h and treated with human IFN-β1a (mammalian,
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