Genetic, transcriptome, proteomic and epidemiological evidence for blood brain barrier disruption and polymicrobial brain invasion as determinant factors in Alzheimer’s disease

C.J. Carter

Hepatitis B pathology has a more benign course in ApoE2-E4 carriers . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. One of a member of scaffold proteins are regulated by and mediating cell attachment, growth factor, and chemokine signalling [37] . CC-BY-NC-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/080333 doi: bioRxiv preprint 8 [ 8 ] CD33 binds to alpha 2-3-or alpha2-6linked sialic acids (N-acetyl neuranimic acid) [43] . These residues bind to the influenza virus and the reovirus [44] and these particular sialic acids are expressed on the surface envelope glycoproteins (B, D and H) of the herpes simplex virion, and are required for viral entry into cells [45] . N-acetyl neuranimic acid is expressed by