Selected article for: "acute respiratory and lymphoma patient"
Author: Gordon, Claire L; Smibert, Olivia C; Holmes, Natasha E; Chua, Kyra Y L; Rose, Morgan; Drewett, George; James, Fiona; Mouhtouris, Effie; Nguyen, Thi H O; Zhang, Wuji; Kedzierski, Lukasz; Rowntree, Louise C; Chua, Brendon Y; Caly, Leon; Catton, Mike G; Druce, Julian; Sait, Michelle; Seemann, Torsten; Sherry, Norelle L; Howden, Benjamin P; Kedzierska, Katherine; Kwong, Jason C; Trubiano, Jason A
Title: Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication
  • Cord-id: lza9s7hs
  • Document date: 2021_8_2
    • ID: lza9s7hs
    Snippet: We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR(+)/CD38(+) activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2–specifi
    Document: We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR(+)/CD38(+) activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2–specific antibody responses were absent and SARS-CoV-2–specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.

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