Author: Katie M. Campbell; Gabriela Steiner; Daniel K. Wells; Antoni Ribas; Anusha Kalbasi
Title: Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles Document date: 2020_4_1
ID: bj454swk_16
Snippet: CD4 T cell responses are also an important aspect of antiviral clearance and memory, but these were not included owing to the limitations in predicting human HLA class II epitopes (12) . Lastly, the HLA binding prediction algorithms used in this study are trained based on antigen binding affinities available in the IEDB. Thus, our results are biased toward previously studied epitopes and HLA haplotypes and unlikely to be exhaustive, particularly .....
Document: CD4 T cell responses are also an important aspect of antiviral clearance and memory, but these were not included owing to the limitations in predicting human HLA class II epitopes (12) . Lastly, the HLA binding prediction algorithms used in this study are trained based on antigen binding affinities available in the IEDB. Thus, our results are biased toward previously studied epitopes and HLA haplotypes and unlikely to be exhaustive, particularly in our list of filtered high-binding pMHC. As a result, we have deposited data for all predicted epitopes, even those with lower pMHC binding affinity.
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