Author: AbdelMassih, Antoine Fakhry; Ye, Jianping; Kamel, Aya; Mishriky, Fady; Ismail, Habiba-Allah; Ragab, Heba Amin; El Qadi, Layla; Malak, Lauris; Abdu, Mariam; El-Husseiny, Miral; Ashraf, Mirette; Hafez, Nada; AlShehry, Nada; El-Husseiny, Nadine; AbdelRaouf, Nora; Shebl, Noura; Hafez, Nouran; Youssef, Nourhan; Afdal, Peter; Hozaien, Rafeef; Menshawey, Rahma; Saeed, Rana; Fouda, Raghda
Title: A multicenter consensus: A role of Furin in the endothelial tropism in obese patients with COVID-19 infection Cord-id: oysw7eo1 Document date: 2020_7_15
ID: oysw7eo1
Snippet: Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae. Obese and diabetic patients, males, and the elderly, have increased serum levels of Furi
Document: Furin, a cleavage enzyme, is increasingly recognized in the pathogenesis of metabolic syndrome. Its cleavage action is an essential activation step for the endothelial pathogenicity of several viruses including SARS-CoV-2. This Furin-mediated endothelial tropism seems to underlie the multi-organ system involvement of COVID-19; which is a feature that was not recognized in the older versions of coronaviridae. Obese and diabetic patients, males, and the elderly, have increased serum levels of Furin, with its increased cellular activity; this might explain why these subgroups are at an increased risk of COVID-19 related complications and deaths. In contrast, smoking decreases cellular levels of Furin, this finding may be at the origin of the decreased severity of COVID-19 in smokers. Chinese herbal derived luteolin is suggested to be putative Furin inhibitor, with previous success against Dengue Fever. Additionally, Furin intracellular levels are largely dependent on concentration of intracellular ions, notably sodium, potassium, and magnesium. Consequently, the use of ion channel inhibitors, such as Calcium Channel blockers or Potassium Channel blockers, can prevent cellular transfection early in the course of the illness. Nicotine patches and Colchicine have also been suggested as potential therapies due to Furin mediated inhibition of COVID-19.
Search related documents:
Co phrase search for related documents- activation step and acute respiratory syndrome coronavirus: 1, 2
- acute respiratory syndrome and low density: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
- acute respiratory syndrome and low density lipoprotein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- acute respiratory syndrome and low viral load effective: 1
- acute respiratory syndrome and lung target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45
- acute respiratory syndrome and magnesium potassium: 1
- acute respiratory syndrome coronavirus and low density: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- acute respiratory syndrome coronavirus and low density lipoprotein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute respiratory syndrome coronavirus and low viral load effective: 1
- acute respiratory syndrome coronavirus and lung target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- low density and magnesium potassium: 1
- low density lipoprotein and magnesium potassium: 1
Co phrase search for related documents, hyperlinks ordered by date