Author: Ethan Fast; Russ B. Altman; Binbin Chen
Title: Potential T-cell and B-cell Epitopes of 2019-nCoV Document date: 2020_2_21
ID: j6y806qu_1
Snippet: and class II is essential for anti-viral T-cell responses (14) . 52 In contrast to B-cell epitopes, T-cell epitopes can be located 53 anywhere in a viral protein since human cells can process and 54 present both intracellular and extracellular viral peptides (15). 55 These immunology principles guide the design of our current . The S protein is a target for antibodies and we model its 3D structure with Discotope2 to identify likely binding sites .....
Document: and class II is essential for anti-viral T-cell responses (14) . 52 In contrast to B-cell epitopes, T-cell epitopes can be located 53 anywhere in a viral protein since human cells can process and 54 present both intracellular and extracellular viral peptides (15). 55 These immunology principles guide the design of our current . The S protein is a target for antibodies and we model its 3D structure with Discotope2 to identify likely binding sites (B-cell epitopes). We scan peptide sequences from individual viral proteins with NetMHCPan4 and MARIA for MHC-I and MHC-II presentation to identify potential T-cell epitopes. Our MHC-I analysis include common alleles for HLA-A, HLA-B, and HLA-C, and our MHC-II analysis include common alleles of HLA-DR.
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