Selected article for: "learning model and machine learning model"
Author: Rishikesh Magar; Prakarsh Yadav; Amir Barati Farimani
Title: Potential Neutralizing Antibodies Discovered for Novel Corona Virus Using Machine Learning
  • Document date: 2020_3_20
    • ID: fn7l93wh_21
    Snippet: We have developed a machine learning model for high throughput screening of synthetic antibodies to discover antibodies that potentially inhibit the COVID-19. Our approach can be widely applied to other viruses where only the sequences of viral coat protein-antibody pairs can be obtained. The ML models were trained on 14 different virus types and achieved over 90% fivefold test accuracy. The out of class prediction is 100% for SARS and 84.61% for.....
    Document: We have developed a machine learning model for high throughput screening of synthetic antibodies to discover antibodies that potentially inhibit the COVID-19. Our approach can be widely applied to other viruses where only the sequences of viral coat protein-antibody pairs can be obtained. The ML models were trained on 14 different virus types and achieved over 90% fivefold test accuracy. The out of class prediction is 100% for SARS and 84.61% for Influenza, demonstrating the power of our model for neutralization prediction of antibodies for novel viruses like COVID-19. Using this model, the neutralization of thousands of hypothetical antibodies was predicted, and 18 antibodies were found to be highly efficient in neutralizing COVID-19. Using MD simulations, the stability of predicted antibodies were checked and 8 stable antibodies were found that can neutralize COVID-19.

    Search related documents:
    Co phrase search for related documents
    • class prediction and novel virus: 1
    • class prediction and SARS 100: 1
    • class prediction and test accuracy: 1
    • different virus type and test accuracy: 1, 2
    • different virus type and virus type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39
    • fivefold test accuracy and test accuracy: 1
    • hypothetical antibody and ML model: 1, 2, 3, 4
    • hypothetical antibody and potentially inhibit: 1, 2, 3
    • hypothetical antibody and potentially inhibit antibody: 1, 2, 3
    • hypothetical antibody and predict antibody: 1, 2, 3
    • hypothetical antibody and stable antibody: 1, 2, 3
    • hypothetical antibody and test accuracy: 1