Author: Mohammad Saeed; Alejandro Ibáñez-Costa; Alejandra María Patiño-Trives; Eduardo Collantes Estevez; María Ángeles Aguirre; Chary López-Pedrera
Title: Genomic convergence of locus-based GWAS meta-analysis identifies DDX11 as a novel Systemic Lupus Erythematosus gene Document date: 2020_4_18
ID: 27szdvgd_52
Snippet: dataset eQTLs were found in 6 significantly expressed genes in the Cordoba dataset. DDX11 expression was modulated by the SNP rs3741869 that showed maximum significance in the DDX11 genomic locus (OASSI locus 19). The other eQTL SNPs modulated expression of genes not found to be significant in this study. Interestingly ITGAM/ITGAX, which are known SLE genes, were regulated by the SNPs rs11574637 and rs9888739, located in TRIM72 and functioned as .....
Document: dataset eQTLs were found in 6 significantly expressed genes in the Cordoba dataset. DDX11 expression was modulated by the SNP rs3741869 that showed maximum significance in the DDX11 genomic locus (OASSI locus 19). The other eQTL SNPs modulated expression of genes not found to be significant in this study. Interestingly ITGAM/ITGAX, which are known SLE genes, were regulated by the SNPs rs11574637 and rs9888739, located in TRIM72 and functioned as cis-eQTLs. author/funder. All rights reserved. No reuse allowed without permission.
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