Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_14
Snippet: To further explore sex differences in TMPRSS2 expression in animal models, we harvested lungs from female and male mice treated with control diet or Enz for > 10 days and analyzed them for protein and mRNA expression. In the case of TMPRSS2, this yielded results consistent with human expression data: i.e., there were no sex-specific changes. Additionally, Enz treatment did not downregulate TMPRSS2 ( Fig. 2A and B) . Given the unchanged AR protein.....
Document: To further explore sex differences in TMPRSS2 expression in animal models, we harvested lungs from female and male mice treated with control diet or Enz for > 10 days and analyzed them for protein and mRNA expression. In the case of TMPRSS2, this yielded results consistent with human expression data: i.e., there were no sex-specific changes. Additionally, Enz treatment did not downregulate TMPRSS2 ( Fig. 2A and B) . Given the unchanged AR protein levels (despite a modest but statistically significant mRNA increase) in Enz-treated males, we infer that TMPRSS2 is not regulated by AR in the lung. Nevertheless, further author/funder. All rights reserved. No reuse allowed without permission.
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