Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_25
Snippet: Limitations of our study include the fact that we cannot rule out cell type-specific differences in sex-associated or androgen-dependent TMPRSS2 regulation in pulmonary tissues. Nevertheless, early autopsy studies of COVID-19 appear to show diffuse viral damage that may suggest that the expression of viral host cell receptors is likely not limited to an isolated pulmonary subset of cells (Barton et al., 2020) . Although we did perform immunohisto.....
Document: Limitations of our study include the fact that we cannot rule out cell type-specific differences in sex-associated or androgen-dependent TMPRSS2 regulation in pulmonary tissues. Nevertheless, early autopsy studies of COVID-19 appear to show diffuse viral damage that may suggest that the expression of viral host cell receptors is likely not limited to an isolated pulmonary subset of cells (Barton et al., 2020) . Although we did perform immunohistochemical staining studies for TMPRSS2 expression in the mouse lung, we encountered different patterns compared to human prostate tissue, in which TMPRSS2 is a membrane/cell surface protein. The mouse lung lacked cytoplasmic and membrane staining but expressed significant nuclear stain. This led us to conclude that much of the antibody binding in mouse was non-specific.
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