Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_28
Snippet: Sexually dimorphic AR expression in an organ not associated with sexual differentiation -the male lung -raises the question of function. This is reminiscent of sexually dimorphic AR protein expression in the male human kidney, in which AR function includes regulating glucocorticoid metabolism and downstream steroid receptor activity . Whether this physiology also occurs in the lung has yet to be determined......
Document: Sexually dimorphic AR expression in an organ not associated with sexual differentiation -the male lung -raises the question of function. This is reminiscent of sexually dimorphic AR protein expression in the male human kidney, in which AR function includes regulating glucocorticoid metabolism and downstream steroid receptor activity . Whether this physiology also occurs in the lung has yet to be determined.
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