Author: Guilbert, Theresa W.; Singh, Anne Marie; Danov, Zoran; Evans, Michael D.; Jackson, Daniel J.; Burton, Ryan; Roberg, Kathy A.; Anderson, Elizabeth L.; Pappas, Tressa E.; Gangnon, Ronald; Gern, James E.; Lemanske, Robert F.
Title: Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma Cord-id: p44wqt3n Document date: 2011_9_30
ID: p44wqt3n
Snippet: Background Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood. Objective To determine the relationship of virus-specific wheezing illnesses and lung function in a longitudinal cohort of children at risk for asthma. Methods Two hundred thirty-eight children were followed prospectively from birth to 8 years of age. Early life viral wheezing resp
Document: Background Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood. Objective To determine the relationship of virus-specific wheezing illnesses and lung function in a longitudinal cohort of children at risk for asthma. Methods Two hundred thirty-eight children were followed prospectively from birth to 8 years of age. Early life viral wheezing respiratory illnesses were assessed by using standard techniques, and lung function was assessed annually by using spirometry and impulse oscillometry. The relationships of these virus-specific wheezing illnesses and lung function were assessed by using mixed-effect linear regression. Results Children with RV wheezing illness demonstrated significantly decreased spirometry values, FEV1 (P = .001), FEV0.5 (P < .001), FEF25-75 (P < .001), and also had abnormal impulse oscillometry measures—more negative reactance at 5 Hz (P < .001)—compared with those who did not wheeze with RV. Children who wheezed with respiratory syncytial virus or other viral illnesses did not have any significant differences in spirometric or impulse oscillometry indices when compared with children who did not. Children diagnosed with asthma at ages 6 or 8 years had significantly decreased FEF25-75 (P = .05) compared with children without asthma. Conclusion Among outpatient viral wheezing illnesses in early childhood, those caused by RV infections are the most significant predictors of decreased lung function up to age 8 years in a high-risk birth cohort. Whether low lung function is a cause and/or effect of RV wheezing illnesses is yet to be determined.
Search related documents:
Co phrase search for related documents- absence presence and additional information: 1, 2, 3
- absence presence and additional study: 1, 2, 3, 4
- absence presence and long short: 1, 2, 3, 4, 5, 6, 7, 8
- absence presence and long term prognosis: 1, 2
- absence presence and longitudinal analysis: 1
- absence presence and longitudinal study: 1, 2, 3, 4, 5, 6
- acceptable test and long short: 1
- acute respiratory illness and additional information: 1, 2, 3
- acute respiratory illness and additional study: 1
- acute respiratory illness and long short: 1, 2, 3
- acute respiratory illness and longitudinal analysis: 1
- acute respiratory illness and longitudinal study: 1, 2, 3, 4, 5, 6, 7, 8, 9
- additional information and long short: 1, 2
- additional information and longitudinal study: 1, 2
- additional study and long short: 1, 2, 3
- additional study and longitudinal analysis: 1
- additional study and longitudinal study: 1, 2, 3, 4, 5, 6, 7, 8
Co phrase search for related documents, hyperlinks ordered by date