Author: Daniela Weiskopf; Katharina S. Schmitz; Matthijs P. Raadsen; Alba Grifoni; Nisreen M.A. Okba; Henrik Endeman; Johannes P.C. van den Akker; Richard Molenkamp; Marion P.G. Koopmans; Eric C.M. van Gorp; Bart L. Haagmans; Rik L. de Swart; Alessandro Sette; Rory Dylan de Vries
Title: Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome Document date: 2020_4_18
ID: 97gme3pl_11
Snippet: As production of pro-inflammatory cytokines can be predictive of severe clinical outcome for other viral diseases 10 , we measured antigen-specific production of 13 cytokines in cell culture supernatants from PBMC stimulated with MP_S ( Figure 1f , IL-21 data not shown), MP_CD4_R and MP_CD8 (data not shown). Activation of PBMC by the overlapping S peptide pool led to a strong significant production of the Th1 cytokines IFNg, TNFa and IL-2 in COVI.....
Document: As production of pro-inflammatory cytokines can be predictive of severe clinical outcome for other viral diseases 10 , we measured antigen-specific production of 13 cytokines in cell culture supernatants from PBMC stimulated with MP_S ( Figure 1f , IL-21 data not shown), MP_CD4_R and MP_CD8 (data not shown). Activation of PBMC by the overlapping S peptide pool led to a strong significant production of the Th1 cytokines IFNg, TNFa and IL-2 in COVID-19 patients when compared to HC.
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