Author: Kim, M.-H.; Salloum, S.; Wang, J. Y.; Wong, L. P.; Regan, J.; Lefteri, K.; Manickas-Hill, Z.; Sadreyev, R.; Li, J. Z.; Yu, X.; Chung, R.
Title: Type I, II, and III interferon signatures correspond to COVID-19 disease severity Cord-id: mj3yhatv Document date: 2021_3_12
ID: mj3yhatv
Snippet: We analyzed the plasma levels of interferons and cytokines, and the expression of interferon-stimulated genes in peripheral blood mononuclear cells in COVID-19 patients with different disease severity. Mild patients exhibited transient type I interferon responses, while ICU patients had prolonged type I interferon responses with hyper- inflammation mediated by interferon regulatory factor 1. Type II interferon responses were compromised in ICU patients. Type III interferon responses were induced
Document: We analyzed the plasma levels of interferons and cytokines, and the expression of interferon-stimulated genes in peripheral blood mononuclear cells in COVID-19 patients with different disease severity. Mild patients exhibited transient type I interferon responses, while ICU patients had prolonged type I interferon responses with hyper- inflammation mediated by interferon regulatory factor 1. Type II interferon responses were compromised in ICU patients. Type III interferon responses were induced in the early phase of SARS-CoV-2 infection, even in convalescent patients. These results highlight the importance of type I and III interferon responses during the early phase of infection in controlling COVID-19 progression.
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