Author: Kasela, Silva; Daniloski, Zharko; Bollepalli, Sailalitha; Jordan, Tristan X.; tenOever, Benjamin R.; Sanjana, Neville E.; Lappalainen, Tuuli
Title: Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus Cord-id: pxbo0qr1 Document date: 2021_8_23
ID: pxbo0qr1
Snippet: To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology. SUPPLEMENTARY INFO
Document: To date, the locus with the most robust human genetic association to COVID-19 severity is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that modulate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-021-02454-4.
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