Pressure-Regulated Ventilator Splitting (PReVentS): A COVID-19 Response Paradigm from Yale University

Micha Sam Brickman Raredon; Clark Fisher; Paul Heerdt; Ranjit Deshpande; Steven Nivison; Elaine Fajardo; Shamsuddin Akhtar; Thomas Raredon; Laura E. Niklason

To obtain these target pressures for each patient, the ventilator and PEEP valves would be set up as described below. The ventilator would be set to pressure-controlled mode, with a ventilator PIP of 40 cmH2O and a ventilator PEEP of 0 cm H2O (Figure 8) . Gas from the ventilator would flow into the inspiratory limb of the circuit, where it would flow across two pressure-gated valves. For Patient #1, the inspiratory pressure-gated valve would be set at 5 cmH2O, resulting in a pressure drop across the valve of 5 cmH2O -therefore, Patient #1 receives a PIP of 35 cmH2O. In contrast, for Patient #2 the pressure-gated valve would be set at 15 cmH2O, resulting in a drop of 15 cmH2O pressure from the ventilator -therefore, Patient #2 receives a PIP of 25 cmH2O (Figure 9 ).