Author: Ali Punjani; Haowei Zhang; David J. Fleet
Title: Non-uniform refinement: Adaptive regularization improves single particle cryo-EM reconstruction Document date: 2019_12_16
ID: bqwmx5dy_15
Snippet: The CV formulation in Eqn. 1 provides great flexibility in choosing the family of regularizers r θ , taking domain knowledge into account. For non-uniform refinement, we wish to accommodate protein structures with spatial variations in disorder, motion, and resolution. Accordingly, we define the regularizer to be a space-varying linear filter. The filter's spatial extent is determined by the regularization parameter θ(x), which varies with spat.....
Document: The CV formulation in Eqn. 1 provides great flexibility in choosing the family of regularizers r θ , taking domain knowledge into account. For non-uniform refinement, we wish to accommodate protein structures with spatial variations in disorder, motion, and resolution. Accordingly, we define the regularizer to be a space-varying linear filter. The filter's spatial extent is determined by the regularization parameter θ(x), which varies with spatial position:
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