Selected article for: "common problem and health problem"
Author: Wang, Xiaojing; Yan, Weiming; Lu, Yulei; Chen, Tao; Sun, Ying; Qin, Xiaomin; Zhang, Jiangguo; Han, Meifang; Guo, Wei; Wang, Hongwu; Wu, Di; Xi, Dong; Luo, Xiaoping; Ning, Qin
Title: CD4–CD8-T cells contribute to the persistence of viral hepatitis by striking a delicate balance in immune modulation
  • Cord-id: mgrf1odm
  • Document date: 2012_12_1
    • ID: mgrf1odm
    Snippet: Viral hepatitis remains the most common cause of liver disease and a major public health problem. Here, we focus on the role of CD4 CD8 double negative T (DN T) cells involved in the mechanisms of viral persistence in hepatitis. C3H/HeJ mice infected with murine hepatitis virus strain 3 (MHV-3) were used to display chronic viral hepatitis. DN T cells dramatically increased in MHV-3 infected mice. Adoptive transfer of DN T cells from MHV-3 infected mice led to a significant increase in mice survi
    Document: Viral hepatitis remains the most common cause of liver disease and a major public health problem. Here, we focus on the role of CD4 CD8 double negative T (DN T) cells involved in the mechanisms of viral persistence in hepatitis. C3H/HeJ mice infected with murine hepatitis virus strain 3 (MHV-3) were used to display chronic viral hepatitis. DN T cells dramatically increased in MHV-3 infected mice. Adoptive transfer of DN T cells from MHV-3 infected mice led to a significant increase in mice survival. The DN T cells with production of IFN-γ and IL-2 are able to kill virus-specific CD8(+) T cells via the Fas/FasL dependent pathway. The delicate balance of multiple effects of DN T cells may lead to viral persistence in MHV-3 induced hepatitis. In short, our study identified DN T cells contributing to viral persistence in MHV-3 induced hepatitis in C3H/HeJ mice, which provides a rationale for modulating DN T cells for the management of viral hepatitis.

    Search related documents:
    Co phrase search for related documents
    • absolute count and acute hepatitis: 1
    • absolute count and acute inflammation: 1
    • absolute count and acute phase: 1, 2, 3, 4, 5, 6, 7, 8
    • absolute count and liver disease: 1
    • absolute count and liver function: 1, 2, 3, 4, 5
    • accumulate evidence and acute hepatitis: 1
    • activation marker and acute hepatitis: 1
    • activation marker and acute inflammation: 1
    • activation marker and acute phase: 1, 2, 3, 4
    • activation marker and adhesion molecule: 1
    • activation marker and liver damage: 1
    • activation marker and liver disease: 1
    • activation marker and liver function: 1
    • acute hepatitis and adhesion molecule: 1
    • acute hepatitis and adoptive transfer: 1, 2, 3, 4, 5, 6
    • acute hepatitis and liver damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • acute hepatitis and liver damage cause: 1
    • acute hepatitis and liver disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute hepatitis and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15