Author: Roni Ben-Ami; Agnes Klochendler; Matan Seidel; Tal Sido; Ori Gurel-Gurevich; Moran Yassour; Eran Meshorer; Gil Benedek; Irit Fogel; Esther Oiknine-Djian; Asaf Gertler; Zeev Rotstein; Bruno Lavi; Yuval Dor; Dana G Wolf; Maayan Salton; Yotam Drier
Title: Pooled RNA extraction and PCR assay for efficient SARS-CoV-2 detection Document date: 2020_4_22
ID: 5s03f0pp_23
Snippet: We provide a tool (https://github.com/matanseidel/pooling_optimization) to help choose the approach and pool size based on the prevalence. Even when matrix pooling is not more efficient, it may have other benefits, as it significantly reduces the need for retesting, and provides additional confidence that a sample is negative as it is detected as negative in two pools. In the case that samples are not independent, and we have information regardin.....
Document: We provide a tool (https://github.com/matanseidel/pooling_optimization) to help choose the approach and pool size based on the prevalence. Even when matrix pooling is not more efficient, it may have other benefits, as it significantly reduces the need for retesting, and provides additional confidence that a sample is negative as it is detected as negative in two pools. In the case that samples are not independent, and we have information regarding their dependency, we can try to further efficiency by grouping together dependent samples, that is, samples that are likely all positives or all negatives, such as members of the same family, or samples that are likely to be all negative since they have a low risk profile. This will increase the number of negative pools, and therefore decrease the overall number of tests conducted.
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