Author: Sultan, Armiya; Ali, Rafat; Sultan, Tahira; Ali, Sher; Khan, Nida Jamil; Parganiha, Arti
Title: Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 M(pro) for pharmacological interventions in COVID-19 pandemic Cord-id: mpxfhc65 Document date: 2021_4_6
ID: mpxfhc65
Snippet: The COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency warranting the development of targeted treatment. The main protease M(pro) is considered as a key drug target in coronavirus infections because of its vital role in the proteolytic processing of two essential polyproteins required for the replication and transcription of viral RNA. Targeting and inhibiting the M(pro) activity represents a valid approach to prevent the SARS-CoV-2 replication and spread. Based on the structure
Document: The COVID-19 pandemic caused by SARS-CoV-2 is a global health emergency warranting the development of targeted treatment. The main protease M(pro) is considered as a key drug target in coronavirus infections because of its vital role in the proteolytic processing of two essential polyproteins required for the replication and transcription of viral RNA. Targeting and inhibiting the M(pro) activity represents a valid approach to prevent the SARS-CoV-2 replication and spread. Based on the structure-assisted drug designing, here we report a circadian clock-modulating small molecule “SRT2183†as a potent inhibitor of M(pro) to block the replication of SARS-CoV-2. The findings are expected to pave the way for the development of therapeutics for COVID-19.
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