Author: Egia-Mendikute, L.; Bosch, A.; Prieto-Fernandez, E.; Lee, S. Y.; Jimenez-Lasheras, B.; Garcia del Rio, A.; Antonana-Vildosola, A.; Bruzzone, C.; Bizkarguenaga, M.; Embade, N.; Abrescia, N. G. A.; Mato, J. M.; Millet, O.; Palazon, A.
Title: Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in Covid-19-naive individuals Cord-id: mj3azj0f Document date: 2020_7_29
ID: mj3azj0f
Snippet: We have developed a novel multiplexed flow cytometric bead array (C19BA) for the detection of SARS-CoV-2 seroconversion that allows sensitive identification of IgG and IgM antibodies against three immunogenic proteins: the spike receptor-binding domain (RBD), the spike protein subunit 1 (S1) and the nucleoprotein (N) simultaneously. This assay is more sensitive than ELISA, and the combination of three antigens allows for the interrogation of full seroconversion. Importantly, we have detected N-r
Document: We have developed a novel multiplexed flow cytometric bead array (C19BA) for the detection of SARS-CoV-2 seroconversion that allows sensitive identification of IgG and IgM antibodies against three immunogenic proteins: the spike receptor-binding domain (RBD), the spike protein subunit 1 (S1) and the nucleoprotein (N) simultaneously. This assay is more sensitive than ELISA, and the combination of three antigens allows for the interrogation of full seroconversion. Importantly, we have detected N-reactive antibodies in COVID-19-negative individuals.
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