Author: Faico-Filho, K. S.; Passarelli, V. C.; Bellei, N.
Title: Is Higher Viral Load in SARS-CoV-2 Associated With Death? Cord-id: janwx5x8 Document date: 2020_8_6
ID: janwx5x8
Snippet: There is no proven prognostic marker or adequate number of studies in patients hospitalized for coronavirus disease 2019 (COVID19). We conducted a retrospective cohort study of patients hospitalized with COVID19 from March 14 to June 17, 2020, at Sao Paulo Hospital. SARSCoV2 viral load was assessed using the cycle threshold (Ct) values obtained from an RTPCR assay applied to the nasopharyngeal swab samples. Disease severity and patient outcomes were compared. Among the 875 patients, 50.1% (439/8
Document: There is no proven prognostic marker or adequate number of studies in patients hospitalized for coronavirus disease 2019 (COVID19). We conducted a retrospective cohort study of patients hospitalized with COVID19 from March 14 to June 17, 2020, at Sao Paulo Hospital. SARSCoV2 viral load was assessed using the cycle threshold (Ct) values obtained from an RTPCR assay applied to the nasopharyngeal swab samples. Disease severity and patient outcomes were compared. Among the 875 patients, 50.1% (439/875) had mild, 30.4% (266/875) moderate, and 19.5% (170/875) severe disease. A Ct value of <25 (472/875) indicated a high viral load, which was independently associated with mortality (OR: 0,34; 95% CI: 0,217 to 0,533; p < 0.0001). Admission SARSCoV2 viral load is an important surrogate biomarker of infectivity and is independently associated with mortality among patients hospitalized with COVID19.
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