Selected article for: "gene expression and host cell"
Author: Myra Hosmillo; Jia Lu; Michael R. McAllaster; James B. Eaglesham; Xinjie Wang; Edward Emmott; Patricia Domingues; Yasmin Chaudhry; Timothy J Fitzmaurice; Matthew K.H. Tung; Marc Panas; Gerald McInerney; Nicholas Locker; Craig B. Willen; Ian Goodfellow
Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation
  • Document date: 2019_3_8
    • ID: d0q5lhf4_4
    Snippet: following viral infection, the formation of which requires the activity of key membrane 23 bound viral enzymes (Altan-Bonnet, 2017) . Within the membrane bound viral 24 replication complex, translation of the viral genome and the synthesis of new viral 25 RNA occurs in a highly coordinated process. Positive sense RNA viruses have 26 evolved novel gene expression mechanisms that enable them to overcome the 27 genome size limitations that accompany.....
    Document: following viral infection, the formation of which requires the activity of key membrane 23 bound viral enzymes (Altan-Bonnet, 2017) . Within the membrane bound viral 24 replication complex, translation of the viral genome and the synthesis of new viral 25 RNA occurs in a highly coordinated process. Positive sense RNA viruses have 26 evolved novel gene expression mechanisms that enable them to overcome the 27 genome size limitations that accompany error-prone replication and which might 28 restrict their overall coding capacity (Firth and Brierley, 2012) . In addition, viral 29 modification of the host cell translation machinery often provides a competitive 30 advantage allowing for the efficient translation of viral RNA in an environment where 31 competing cellular RNAs are in abundance (McCormick and Khaperskyy, 2017) . 32

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