Author: Steven Henikoff; Jorja G. Henikoff
Title: Profiling the epigenome at home Document date: 2020_4_17
ID: mojf4l6b_59
Snippet: We conclude that five CUT&Tag@home histone H3 methylation profiles segment the human genome at high-resolution into active promoters, enhancers, gene bodies, developmentally silenced domains and constitutively silenced endogenous retroviruses. Whereas chromatin accessibility profiling maps only enhancers and promoters without distinguishing between them (e.g. the ATAC-seq track in Figure 5 ), CUT&Tag using histone methylation antibodies captures .....
Document: We conclude that five CUT&Tag@home histone H3 methylation profiles segment the human genome at high-resolution into active promoters, enhancers, gene bodies, developmentally silenced domains and constitutively silenced endogenous retroviruses. Whereas chromatin accessibility profiling maps only enhancers and promoters without distinguishing between them (e.g. the ATAC-seq track in Figure 5 ), CUT&Tag using histone methylation antibodies captures the extraordinary richness of the full epigenome.
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