Author: Alessandra Renieri; Elisa Benetti; Rossella Tita; Ottavia Spiga; Andrea Ciolfi; Giovanni Birolo; Alessandro Bruselles; Gabriella Doddato; Annarita Giliberti; Cterina Marconi; Francesco Musacchia; Tommaso Pippucci; Annalaura Torella; Alfonso Trezza; Floriana Valentino; Mrgherita Baldassarri; Alfredo Brusco; Rosanna Asselta; Bruttini Mirella; Simone Furini; Marco Seri; Vincenzo Nigro; Giuseppe Matullo; Marco Tartaglia; Francesca Mari; Annamaria Pinto
Title: ACE2 variants underlie interindividual variability and susceptibility to COVID-19 in Italian population Document date: 2020_4_6
ID: klj710h2_2
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.20047977 doi: medRxiv preprint A high sequence homology has been shown between SARS-associated coronavirus (SARS-CoV) and 2019-nCov (6) . Recent studies modelled the spike protein to identify the receptor for 2019-nCov, and indicated that angiotensin converting enzyme 2 (ACE2) is the receptor for this novel coronavirus (7, 8) . Zhou et.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.20047977 doi: medRxiv preprint A high sequence homology has been shown between SARS-associated coronavirus (SARS-CoV) and 2019-nCov (6) . Recent studies modelled the spike protein to identify the receptor for 2019-nCov, and indicated that angiotensin converting enzyme 2 (ACE2) is the receptor for this novel coronavirus (7, 8) . Zhou et. al. conducted virus infectivity studies and showed that ACE2 is essential for 2019-nCov to enter HeLa cells (9) . Although the binding strength between 2019-nCov and ACE2 is weaker than that between SARS-CoV and ACE2, it is considered as much high as threshold necessary for virus infection. The spike glycoprotein (S-protein), a trimeric glycoprotein in the virion surface (giving the name of crown -corona in latin-), mediates receptor recognition throughout its receptor binding domain (RBD) and membrane fusion (10,11). Based on recent reports, 2019-nCov protein binds to ACE2 through Leu455, Phe486, Gln493, Asn501, and Tyr505. It has been postulated that residues 31, 41, 82, 353, 355, and 357 of the ACE2 receptor map to the surface of the protein interacting with 2019-nCov spike protein (12), as previously documented for SARS-CoV.
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