Prediction and Evolution of B Cell Epitopes of Surface Protein in SARS-CoV-2

Jerome R Lon; Yunmeng Bai; Bingxu Zhong; Fuqiang Cai; Hongli Du

All of the epitope A, B, C, D located on the surface of the tail of the S protein, which is relatively easy to bind. The epitope E is located on the head of the S protein, which is the key area where the S protein recognizes and binds to ACE2 [12, 13] , has the potential to block the infection process. The epitope F and the epitope G located on the end of the head of the E protein, the two epitopes coincide, this may due to they are all consecutive and the secondary structure avoided the α-helix and the β-sheet. The epitope H is derived from the M protein, the structure and conservation could not be determined due to the inability to predict reliable structure. However, it could be known from the surface probablity scores that the epitope H is more likely to be located on the surface of the M protein.