Selected article for: "ground glass multiple mottling opacity and multiple mottling"
Author: Lian, Jiangshan; jin, Ciliang; Hao, Shaorui; Zhang, Xiaoli; Yang, Meifang; Jin, Xi; Lu, Yingfeng; Hu, Jianhua; Zhang, Shanyan; Zheng, Lin; Jia, Hongyu; Cai, Huan; Zhang, Yimin; Yu, Guodong; Wang, Xiaoyan; Gu, Jueqing; Ye, Chanyuan; Yu, Xiaopeng; Gao, Jianguo; Yang, Yida; Sheng, Jifang
Title: High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study
  • Cord-id: murx7tlp
  • Document date: 2020_7_30
    • ID: murx7tlp
    Snippet: This retrospective cohort study aimed to investigate the correlation of the neutrophil-to-lymphocyte ratio (NLR) with critical illness in older patients with COVID-19, and evaluate the prognostic power of the NLR at admission. We enrolled 232 patients with COVID-19, aged ≥60 y, in Zhejiang province from January 17 to March 3, 2020. Primary outcomes were evaluated until April 13. Cox regression was performed for prognostic factors. Twenty-nine (12.5%) patients progressed to critical illness. Ag
    Document: This retrospective cohort study aimed to investigate the correlation of the neutrophil-to-lymphocyte ratio (NLR) with critical illness in older patients with COVID-19, and evaluate the prognostic power of the NLR at admission. We enrolled 232 patients with COVID-19, aged ≥60 y, in Zhejiang province from January 17 to March 3, 2020. Primary outcomes were evaluated until April 13. Cox regression was performed for prognostic factors. Twenty-nine (12.5%) patients progressed to critical illness. Age, shortness of breath, comorbidities including hypertension, heart disease, and chronic obstructive pulmonary disease, higher NLR, lower albumin levels, and multiple mottling and ground-glass opacity were associated with progression. In the multivariate analysis, older age (hazard ratio [HR] 1.121, confidence interval [CI] 1.070-1.174, P<0.001), heart disease (HR 2.587, CI 1.156-5.787, P=0.021), higher NLR (HR 1.136, CI 1.094-1.180, P < 0.001), and multiple mottling and ground-glass opacity (HR 4.518, CI 1.906-10.712, P<0.001) remained critical illness predictors. The NLR was independently associated with progression to critical illness; the relationship was significant and graded (HR: 1.16 per unit; 95% CI: 1.10-1.22; P for trend < 0.001). Therefore, NLR can be adopted as a prognostic tool to assist healthcare providers predict the clinical outcomes of older patients suffering from COVID-19.

    Search related documents:
    Co phrase search for related documents
    • acute respiratory distress syndrome and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome and liver cirrhosis: 1, 2, 3, 4, 5
    • acute respiratory distress syndrome and lung infiltration: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome and lung transplantation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome and lymphocyte level: 1, 2, 3, 4, 5, 6, 7
    • acute respiratory distress syndrome and lymphocyte neutrophil: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory distress syndrome and lymphocyte neutrophil ratio: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • admission collect and lymphocyte neutrophil: 1
    • admission collect and lymphocyte neutrophil ratio: 1
    • admission day and liver cirrhosis: 1, 2, 3
    • admission day and lung infiltration: 1
    • admission day and lung transplantation: 1
    • admission day and lymphocyte level: 1, 2
    • admission day and lymphocyte neutrophil: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • admission day and lymphocyte neutrophil ratio: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • liver cirrhosis and lung transplantation: 1
    • liver cirrhosis and lymphocyte neutrophil: 1, 2, 3
    • liver cirrhosis and lymphocyte neutrophil ratio: 1
    • lung infiltration and lymphocyte level: 1