Author: de Silva, Thushan I.; Liu, Guihai; B Lindsey, Benjamin; Dong, Danning; Shah, Dhruv; J. Mentzer, Alexander; Angyal, Adrienn; Brown, Rebecca; D. Parker, Matthew; Ying, Zixi; Yao, Xuan; Turtle, Lance; Dunachie, Susanna; K. Maini, Mala; Ogg, Graham; Knight, Julian C.; Peng, Yanchun; Rowland-Jones, Sarah L.; Dong, Tao
Title: The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells Cord-id: q3hswyuf Document date: 2021_4_8
ID: q3hswyuf
Snippet: We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T-cells assessed by IFN-γ and cytotoxic killing assays. These data demonstrate the potential for T-cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T-cell as well as humoral immunity.
Document: We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T-cells assessed by IFN-γ and cytotoxic killing assays. These data demonstrate the potential for T-cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T-cell as well as humoral immunity.
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