Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_13
Snippet: We next simulated possible dose response curves of antiviral efficacy, which capture the percentage of viral replication eliminated, according to micromolar concentration of drug. The percent of viral replication suppression at a given intracellular drug concentration is dependent on the intracellular EC50 of the drug, or the concentration of drug required to lower viral replication by 50% (Fig 3d) . Of note the intracellular EC50 is unknown for .....
Document: We next simulated possible dose response curves of antiviral efficacy, which capture the percentage of viral replication eliminated, according to micromolar concentration of drug. The percent of viral replication suppression at a given intracellular drug concentration is dependent on the intracellular EC50 of the drug, or the concentration of drug required to lower viral replication by 50% (Fig 3d) . Of note the intracellular EC50 is unknown for remdesivir, particularly in vivo, making predictions of clinical trial outcomes impossible.
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