Author: Ashish Goyal; E. Fabian Cardozo-Ojeda; Joshua T Schiffer
Title: Potency and timing of antiviral therapy as determinants of duration of SARS CoV-2 shedding and intensity of inflammatory response Document date: 2020_4_14
ID: d7stppv5_23
Snippet: We next assessed which unknown variables in our therapeutic model were most predictive of relevant therapeutic outcomes. As independent variables, we selected in vivo intracellular EC50, because the potency of remdesivir against SARS CoV-2 in humans is unknown, and infection duration at the time of treatment initiation. As dependent variables, we selected shedding duration and viral area under the curve because it is unclear which of these outcom.....
Document: We next assessed which unknown variables in our therapeutic model were most predictive of relevant therapeutic outcomes. As independent variables, we selected in vivo intracellular EC50, because the potency of remdesivir against SARS CoV-2 in humans is unknown, and infection duration at the time of treatment initiation. As dependent variables, we selected shedding duration and viral area under the curve because it is unclear which of these outcomes is a stronger predictor of progression to cytokine storm and respiratory failure, as well as transmissibility, in infected people. We also included the final tally of effector cells as this outcome may also be predictive of likelihood of cytokine storm (20) .
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