Effectiveness of the BNT162b2 mRNA Covid-19 vaccine in Spanish healthcare workers.

Núñez López, Concepción; González de Abreu, Juan Manuel; Pérez-Blanco, Verónica; de Miguel Buckley, Rosa; Romero Gómez, María Pilar; Díaz-Menéndez, Marta; Núñez López, C; de Abreu, J M González; Pérez-Blanco, V; de Miguel Buckley, R; Romero Gómez, M. P; Díaz-Menéndez, M

INTRODUCTION Frontline health care workers (HCW) have higher risk than the general population to become infected by SARS.CoV.2, so they were a priority group for Covid-19 vaccine administration. We compared the incidence and prevalence of HCW infected pre-and post-vaccination with the BNT162b2 mRNA COVID-19 vaccine. MATERIAL AND METHODS Prospective observational study carried out between 01/12/20 and 07/03/21 in La Paz University Hospital, Madrid (Spain). SARS.CoV.2 positive cases in HCW after vaccination were collected and compared to those hospitalized COVID-19 patients at the same hospital. RESULTS Two weeks after finishing the first round of vaccinations daily new cases of HCW infections (symptomatic and asymptomatic) decreased substantially and cumulative cases of infected HCW and hospitalized COVID-19 patients started to diverge. No new positive cases of HCW infection were registered seven days after the second dose of BNT162b2 mRNA COVID-19 vaccine. CONCLUSIONS BNT162b2 mRNA COVID-19 vaccine is highly effective in Spanish HCW.