Author: Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho
Title: Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19 Document date: 2020_4_9
ID: hbystii6_17
Snippet: The corresponding proteins of the DEG shared with the list of DEG from libraries for virus perturbations were queried in the STRING database (Search Tool for Retrieval of Interacting Genes, version 10.5; https://string-db.org/) 35 , for the construction of PPI networks. We considered the following settings: text mining, experiments, databases, and co-expression as sources of active interaction. We selected the minimum interaction score of 0.900 (.....
Document: The corresponding proteins of the DEG shared with the list of DEG from libraries for virus perturbations were queried in the STRING database (Search Tool for Retrieval of Interacting Genes, version 10.5; https://string-db.org/) 35 , for the construction of PPI networks. We considered the following settings: text mining, experiments, databases, and co-expression as sources of active interaction. We selected the minimum interaction score of 0.900 (highest confidence), and the disconnected nodes were hidden to simplify the display. We evaluated the PPI enrichment P-values, which verifies the number of interactions of a set of proteins compared with a random set of similar size. The PPI enrichment P-value represents the statistical significance provided by STRING. Access in March 2020.
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