Author: Katie M. Campbell; Gabriela Steiner; Daniel K. Wells; Antoni Ribas; Anusha Kalbasi
Title: Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles Document date: 2020_4_1
ID: bj454swk_17
Snippet: With the ongoing SARS-CoV-2 pandemic, there are worldwide efforts to collect blood and tissue samples from persons who are asymptomatic, symptomatic with limited or serious complications, and convalescent. It is possible that patients who have the most severe forms of the disease, including ARDS, may have an increased functionality of CD8 T cells recognizing specific antigens presented by one of their HLAs, which could be specifically studied usi.....
Document: With the ongoing SARS-CoV-2 pandemic, there are worldwide efforts to collect blood and tissue samples from persons who are asymptomatic, symptomatic with limited or serious complications, and convalescent. It is possible that patients who have the most severe forms of the disease, including ARDS, may have an increased functionality of CD8 T cells recognizing specific antigens presented by one of their HLAs, which could be specifically studied using the predicted epitopes described herein. In addition, preventive vaccines may require monitoring not only the induction of an antibody response, which is usually delayed, but also an earlier CD8 T cell response to specific antigens within the context of the patient's HLA subtypes. Given the global reach of the SARS-CoV-2 pandemic, this database of predicted HLA class I binding peptides may serve as a guide to identify and monitor phenotypic, functional and kinetic responses of putative SARS-CoV-2-specific CD8 + T cells across patients with a broad range of HLA haplotypes internationally.
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