Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19

Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho

Although the genes and pathways we highlighted here were identified based on a robust statistical significance, we emphasize that other methods of over-time gene expression analyses applying different cutoffs could be considered; using GTEx V8 cohort or separating males and females may result in different sets of age-related genes in the lung. Further analyses should be conducted to identify more functional differences between male and female lungs during aging. Moreover, clinical data from these individuals -such as diabetes or heart disease -important factors influencing . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.07.030767 doi: bioRxiv preprint COVID-19 outcome -were not evaluated. However, due to the nature of GTEx donor consent, public phenotypes (including clinical data) are limited. Access to the protected phenotypes of the individuals needs an application via dbGaP (Genotypes and Phenotypes database), which, associated with reanalysis of the transcriptomics data, may take a significant amount of time. Part of the results presented herein derives from a previously unpublished paper focusing on aging lung on a different topic. Nevertheless, we decided to release this data focusing on SARS-CoV-2, due to the emergency of the current pandemic.