Author: Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho
Title: Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19 Document date: 2020_4_9
ID: hbystii6_8
Snippet: In conclusion, we show that lung gene expression of TRIB3, a protein predicted to interact with the nucleocapsid protein and the RNA-dependent RNA polymerase of HCoVs, decreases specifically in males during aging. This study provides insights into aging and COVID-19 based on the transcriptional profile of the aging lung and reveals a potential role for TRIB3, surfactant metabolism, and mitotic cell cycle. Considering that TRIB3 may decrease virus.....
Document: In conclusion, we show that lung gene expression of TRIB3, a protein predicted to interact with the nucleocapsid protein and the RNA-dependent RNA polymerase of HCoVs, decreases specifically in males during aging. This study provides insights into aging and COVID-19 based on the transcriptional profile of the aging lung and reveals a potential role for TRIB3, surfactant metabolism, and mitotic cell cycle. Considering that TRIB3 may decrease virus infection and replication, strategies to stimulate TRIB3 expression should be tested for the treatment of COVID-
Search related documents:
Co phrase search for related documents- nucleocapsid protein and replication virus infection: 1, 2, 3, 4, 5, 6
- nucleocapsid protein and replication virus infection decrease: 1, 2
- nucleocapsid protein and RNA dependent HCoVs RNA polymerase: 1, 2
- nucleocapsid protein and RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- nucleocapsid protein and surfactant metabolism: 1, 2
- nucleocapsid protein and treatment test: 1
- nucleocapsid protein and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- potential role and replication virus infection: 1, 2, 3, 4
- potential role and RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- potential role and study insight provide: 1
- potential role and transcriptional profile: 1
- potential role and treatment test: 1, 2, 3
- potential role and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- replication virus infection and RNA dependent HCoVs RNA polymerase: 1, 2
- replication virus infection and RNA polymerase: 1, 2, 3, 4, 5, 6, 7, 8, 9
- replication virus infection and surfactant metabolism: 1, 2
- replication virus infection and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
- replication virus infection decrease and RNA dependent HCoVs RNA polymerase: 1, 2
- replication virus infection decrease and RNA polymerase: 1, 2
Co phrase search for related documents, hyperlinks ordered by date