Selected article for: "gene expression and virus replication"
Author: Diogo de Moraes; Brunno Vivone Buquete Paiva; Sarah Santiloni Cury; João Pessoa Araújo Junior; Marcelo Alves da Silva Mori; Robson Francisco Carvalho
Title: Prediction of SARS-CoV interaction with host proteins during lung aging reveals a potential role for TRIB3 in COVID-19
  • Document date: 2020_4_9
    • ID: hbystii6_8
    Snippet: In conclusion, we show that lung gene expression of TRIB3, a protein predicted to interact with the nucleocapsid protein and the RNA-dependent RNA polymerase of HCoVs, decreases specifically in males during aging. This study provides insights into aging and COVID-19 based on the transcriptional profile of the aging lung and reveals a potential role for TRIB3, surfactant metabolism, and mitotic cell cycle. Considering that TRIB3 may decrease virus.....
    Document: In conclusion, we show that lung gene expression of TRIB3, a protein predicted to interact with the nucleocapsid protein and the RNA-dependent RNA polymerase of HCoVs, decreases specifically in males during aging. This study provides insights into aging and COVID-19 based on the transcriptional profile of the aging lung and reveals a potential role for TRIB3, surfactant metabolism, and mitotic cell cycle. Considering that TRIB3 may decrease virus infection and replication, strategies to stimulate TRIB3 expression should be tested for the treatment of COVID-

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