Author: Shen Xu; Lin Fu; Jun Fei; Hui-Xian Xiang; Ying Xiang; Zhu-Xia Tan; Meng-Die Li; Fang-Fang Liu; Ying Li; Ming-Feng Han; Xiu-Yong Li; De-Xin Yu; Hui Zhao; De-Xiang Xu
Title: Acute kidney injury at early stage as a negative prognostic indicator of patients with COVID-19: a hospital-based retrospective analysis Document date: 2020_3_26
ID: b4ay5vyp_2
Snippet: Novel coronavirus China. 2020; https://www.who.int/csr/don/12-january-2020-novelcoronavirus-china/en/ ). On February12, 2020, the International Committee on SARS-CoV-2 is mainly transmitted by droplets or direct contact and infected through respiratory tract 2 . In addition, SARS-CoV-2 can also be transmitted by feces 3 . Accumulating data demonstrate that SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) to enter human cells, mainly pulmona.....
Document: Novel coronavirus China. 2020; https://www.who.int/csr/don/12-january-2020-novelcoronavirus-china/en/ ). On February12, 2020, the International Committee on SARS-CoV-2 is mainly transmitted by droplets or direct contact and infected through respiratory tract 2 . In addition, SARS-CoV-2 can also be transmitted by feces 3 . Accumulating data demonstrate that SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) to enter human cells, mainly pulmonary epithelial cells, and probably cardiomyocytes and renal tubular epithelial cells [4] [5] [6] . The main symptoms and signs of COVID-19 patients are fever, companied by dry cough, dyspnea, diarrhea, fatigue and lymphopenia [7] [8] [9] [10] [11] . Although only a few cases died in mild COVID-19 patients, death risk was rapidly increased among critical ill patients with the fatality rate even more than 50% 12 . A large number of clinical data have revealed that infection with SARS-CoV-2 not only causes severe acute respiratory syndrome but also multiple organ injuries, including myocardial dysfunction, hepatic injury and even acute renal failure (AKI) 13 . Nevertheless, what factors influence the multiple organ injuries, especially AKI, during the pathogenesis of COVID-19 remains unclear. Moreover, the clinical significance of AKI needs to be further clarified.
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