Author: Zergane, Meryam; Kuebler, Wolfgang M.; Michalick, Laura
Title: Heteromeric TRP Channels in Lung Inflammation Cord-id: qu5chs72 Document date: 2021_7_1
ID: qu5chs72
Snippet: Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca(2+) influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells and formation of pulmonary edema. Interestingly, TRP channel subunits can build heterotetramers, whereas heteromeric TRPC1/4, TRPC3/6 and TRPV1/4 are ex
Document: Activation of Transient Receptor Potential (TRP) channels can disrupt endothelial barrier function, as their mediated Ca(2+) influx activates the CaM (calmodulin)/MLCK (myosin light chain kinase)-signaling pathway, and thereby rearranges the cytoskeleton, increases endothelial permeability and thus can facilitate activation of inflammatory cells and formation of pulmonary edema. Interestingly, TRP channel subunits can build heterotetramers, whereas heteromeric TRPC1/4, TRPC3/6 and TRPV1/4 are expressed in the lung endothelium and could be targeted as a protective strategy to reduce endothelial permeability in pulmonary inflammation. An update on TRP heteromers and their role in lung inflammation will be provided with this review.
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