Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study

Lin Fu; Jun Fei; Shen Xu; Hui-Xian Xiang; Ying Xiang; Zhu-Xia Tan; Meng-Die Li; Fang-Fang Liu; Ying Li; Ming-Feng Han; Xiu-Yong Li; Hui Zhao; De-Xiang Xu

Further analysis showed that the levels of alkaline phosphatase and glutamyl transferase were slightly increased in COVID-19 patients with diabetes as compared with those without diabetes. By contrast, the level of albumin was slightly decreased in COVID-19 patients with diabetes as compared with those without diabetes. Of interest, there was no significant association between hepatic functional indexes and comorbidity with liver disease (Table 2) . Finally, the association between blood lymphocytes and ALI was analyzed among COVID-19 patients. As shown in Table 2 , the levels of ALT and glutamyl transferase were higher in COVID-19 patients with lymphopenia than those without lymphopenia. By contrast, the levels of albumin and globulin were lower in COVID-19 patients with lymphopenia than those without lymphopenia ( CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.