Author: Rojas, Armando; Lindner, Cristian; Gonzà lez, Ileana; Morales, Miguel Angel
Title: Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients Cord-id: qw3zy9g0 Document date: 2021_5_15
ID: qw3zy9g0
Snippet: Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products (RAGE) in orchestrating a plethora of proinflammatory cellular responses leading to many of the complications and end-organ damages reported in patients with diabetes mellitus (DM). During the coronavirus disease 2019 (COVID-19) pandemic, many clinical reports have pointed out that DM increases the risk of COVID-19 complications,
Document: Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial role of the receptor for advanced-glycation end-products (RAGE) in orchestrating a plethora of proinflammatory cellular responses leading to many of the complications and end-organ damages reported in patients with diabetes mellitus (DM). During the coronavirus disease 2019 (COVID-19) pandemic, many clinical reports have pointed out that DM increases the risk of COVID-19 complications, hospitalization requirements, as well as the overall severe acute respiratory syndrome coronavirus 2 case-fatality rate. In the present review, we intend to focus on how the basal activation state of the RAGE axis in common preexisting conditions in DM patients such as endothelial dysfunction and hyperglycemia-related prothrombotic phenotype, as well as the contribution of RAGE signaling in lung inflammation, may then lead to the increased mortality risk of COVID-19 in these patients. Additionally, the cross-talk between the RAGE axis with either another severe acute respiratory syndrome coronavirus 2 receptor molecule different of angiotensin-converting enzyme 2 or the renin-angiotensin system imbalance produced by viral infection, as well as the role of this multi-ligand receptor on the obesity-associated low-grade inflammation in the higher risk for severe illness reported in diabetes patients with COVID-19, are also discussed.
Search related documents:
Co phrase search for related documents- ace angiotensin ii and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- ace angiotensin ii and adipose tissue: 1, 2, 3
- ace angiotensin ii imbalance and acute respiratory syndrome: 1
- activate capacity and acute ards respiratory distress syndrome: 1
- activate capacity and acute respiratory syndrome: 1
- activation recruitment and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6, 7, 8
- activation recruitment and acute lung inflammation: 1
- activation recruitment and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- activation recruitment and adipose tissue: 1, 2
- activation state and acute ards respiratory distress syndrome: 1, 2
- activation state and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- activation state and adipose tissue: 1, 2
- activation transcription and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5, 6
- activation transcription and acute lung inflammation: 1, 2
- activation transcription and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- activation transcription and adipose tissue: 1
- activation transcription factor and acute ards respiratory distress syndrome: 1, 2, 3, 4
- activation transcription factor and acute lung inflammation: 1
- activation transcription factor and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7
Co phrase search for related documents, hyperlinks ordered by date