Prediction of SARS-CoV-2 epitopes across 9360 HLA class I alleles

Katie M. Campbell; Gabriela Steiner; Daniel K. Wells; Antoni Ribas; Anusha Kalbasi

. CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.30.016931 doi: bioRxiv preprint . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.30.016931 doi: bioRxiv preprint Figure 2 . SARS-CoV-2 Class I epitome This figure displays all combinations (pMHCs; n=6,493) across peptides (x-axis) properly assigned to protein annotations (bottom color bar) with a binding affinity to HLA alleles (y-axis) of less than 500nM. The heatmap shows the binding affinity (fill color, nM), and pairs without high-binding epitopes are black. The bar charts show the number of peptides corresponding to each peptide (top) or the number of peptides corresponding to each allele (side left). Each allele is annotated (side color bars) by its gene (HLA-A, -B, -C) , whether it is part of the A02 allele group, and superfamily (if available).