Selected article for: "clinical improvement and respiratory distress"
Author: Pilotto, Andrea; Odolini, Silvia; Stefano Masciocchi, S; Comelli, Agnese; Volonghi, Irene; Gazzina, Stefano; Nocivelli, Sara; Pezzini, Alessandro; Focà, Emanuele; Caruso, Arnaldo; Leonardi, Matilde; Pasolini, Maria Pia; Roberto Gasparotti, R; Francesco Castelli, F; Ashton, Nicholas J.; Blennow, Kaj; Zetterberg, Henrik; Padovani, Alessandro
Title: Steroid‐responsive encephalitis in Covid‐19 disease
  • Cord-id: jtrtv2xt
  • Document date: 2020_5_17
    • ID: jtrtv2xt
    Snippet: Covid‐19 infection has the potential for targeting the central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. Here we described the case of a 60‐year old subject with SARS‐CoV‐2 infection but only mild respiratory abnormalities who developed an akinetic mutism due to encephalitis. MRI was negative whereas EEG showed generalized theta slowing. CSF analyses during the acute stage were negative for SARS‐CoV‐2, positive
    Document: Covid‐19 infection has the potential for targeting the central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. Here we described the case of a 60‐year old subject with SARS‐CoV‐2 infection but only mild respiratory abnormalities who developed an akinetic mutism due to encephalitis. MRI was negative whereas EEG showed generalized theta slowing. CSF analyses during the acute stage were negative for SARS‐CoV‐2, positive for pleocytosis and hyperproteinorrachia, and showed increased IL‐8 and TNF‐α concentrations while other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of CSF parameters was observed after high‐dose steroid treatment, thus arguing for an inflammatory‐mediated brain involvement related to Covid‐19. This article is protected by copyright. All rights reserved.

    Search related documents:
    Co phrase search for related documents
    • abnormal inflammation and magnetic resonance: 1, 2, 3
    • abnormal remain and lopinavir ritonavir: 1
    • abnormal remain and magnetic resonance: 1, 2
    • acute sars respiratory distress syndrome and admission day: 1, 2
    • acute sars respiratory distress syndrome and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8
    • acute sars respiratory distress syndrome and lopinavir ritonavir antiviral therapy: 1
    • acute sars respiratory distress syndrome and magnetic resonance: 1, 2, 3
    • acyclovir ampicillin empirical treatment and lopinavir ritonavir: 1
    • acyclovir ampicillin empirical treatment and lopinavir ritonavir antiviral therapy: 1
    • acyclovir ampicillin empirical treatment and lumbar puncture: 1
    • acyclovir ampicillin empirical treatment and lymphocytic pleocytosis: 1
    • acyclovir ampicillin empirical treatment and magnetic resonance: 1
    • admission day and lombardy region: 1
    • admission day and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • admission day and lopinavir ritonavir antiviral therapy: 1
    • admission day and lumbar puncture: 1, 2, 3, 4, 5
    • admission day and lymphocytic pleocytosis: 1
    • admission day and magnetic resonance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • lombardy region and lopinavir ritonavir: 1, 2