Selected article for: "low level and persistently low level"
Author: Zuo, Jun; Stohlman, Stephen A.; Parra, Gabriel I.; Bergmann, Cornelia C.
Title: IL-15 INDEPENDENT MAINTENANCE OF VIRUS-SPECIFIC CD8(+) T CELLS IN THE CNS DURING CHRONIC INFECTION
  • Cord-id: jwglalgx
  • Document date: 2009_2_1
    • ID: jwglalgx
    Snippet: The role of IL-15 in T cell survival was examined during chronic CNS coronavirus infection. Similar numbers of virus-specific CD8(+) T cells were retained in the CNS of IL-15(−/−)and wt mice, consistent with loss of IL-2/15 receptor (CD122) expression. IL-15 deficiency also had no affect on IL-7 receptor (CD127) expression, Bcl-2 upregulation, granzyme B expression, or IFN-γ secretion in CNS persisting CD8(+) T cells. Furthermore, CD8(+) T cell division in the CNS was reduced compared to sp
    Document: The role of IL-15 in T cell survival was examined during chronic CNS coronavirus infection. Similar numbers of virus-specific CD8(+) T cells were retained in the CNS of IL-15(−/−)and wt mice, consistent with loss of IL-2/15 receptor (CD122) expression. IL-15 deficiency also had no affect on IL-7 receptor (CD127) expression, Bcl-2 upregulation, granzyme B expression, or IFN-γ secretion in CNS persisting CD8(+) T cells. Furthermore, CD8(+) T cell division in the CNS was reduced compared to spleen. CD8(+) T cells in the persistently infected CNS are thus characterized by IL-15 independent, low level proliferation and an activated/memory phenotype.

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