The effect of dexamethasone on labor induction: a systematic review.

Mohaghegh, Zaynab; Faal Siahkal, Shahla; Bahmaei, Hadis; Sharifipour, Foruzan; Leyli, Ehsan Kazemnejad; Zahedian, Maryam

BACKGROUND To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor. METHODS The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2021. Two types of articles were included: a) full-text articles published in English or any other languages, and b) Randomized Controlled Trials (RCTs). Participants were primi- or multigravida women with term or post-term pregnancy. The intervention group received parenteral or extra-amniotic dexamethasone whereas the control group received normal saline or no treatment before initiation of labor induction. All data were analyzed using Review Manager 5.3. RESULTS Seventeen studies involving 1879 patients were included in the meta-analysis. Administration of dexamethasone reduced the interval between the initiation of labor induction and the beginning of active phase by about 70 min [MD: - 1.17 (- 1.37, - 1.00); P < 0.00001]. Duration of the first stage of labor in the dexamethasone group was about 88 min shorter than that in the control. There were no maternal and fetal adverse effects. CONCLUSIONS Dexamethasone could significantly reduce the length of induction-active phase interval, and length of the first stage of labor, with no difference in maternal or fetal adverse effects.