Author: Maja von Cube; Marlon Grodd; Martin Wolkewitz; Derek Hazard; Jerome Lambert
Title: Harmonizing heterogeneous endpoints in COVID-19 trials without loss of information - an essential step to facilitate decision making Document date: 2020_4_3
ID: bsddxgx2_11
Snippet: Robust endpoints ensuring assessment of information for clinicians as well as public health authorities are duration of mechanical ventilation, hospitalization and mortality. Six (23%) studies consider mechanical ventilation in the primary endpoint and eight (35%) in the secondary endpoint. Similarly, hospitalization is included in the primary endpoint in seven (30%) of the studies and six (23%) in the secondary endpoint. Sixteen (70%) of the stu.....
Document: Robust endpoints ensuring assessment of information for clinicians as well as public health authorities are duration of mechanical ventilation, hospitalization and mortality. Six (23%) studies consider mechanical ventilation in the primary endpoint and eight (35%) in the secondary endpoint. Similarly, hospitalization is included in the primary endpoint in seven (30%) of the studies and six (23%) in the secondary endpoint. Sixteen (70%) of the studies indicate that information on mortality is recorded (n=10, 43%) primary endpoint, (n=6, 23%, secondary endpoint). For other studies it is unclear whether this information is available. However, it can be presumed that more trials will record this information.
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