Author: Cody S. Nelson; Tori Huffman; Eduardo Cisneros de la Rosa; Guanhua Xie; Nathan Vandergrift; Robert F. Pass; Justin Pollara; Sallie R. Permar
Title: HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions Document date: 2018_1_11
ID: bxqc9a7f_32
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/246884 doi: bioRxiv preprint 12 cell activation was inversely correlated with several parameters in cluster 1 (phagocytosis, gB-246 binding). Finally, some epitope-specific responses correlated with antibody function, including 247 gB domain II-specific IgG responses with phagocytosis activity and AD-2 and domain I-specific 248 IgG.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/246884 doi: bioRxiv preprint 12 cell activation was inversely correlated with several parameters in cluster 1 (phagocytosis, gB-246 binding). Finally, some epitope-specific responses correlated with antibody function, including 247 gB domain II-specific IgG responses with phagocytosis activity and AD-2 and domain I-specific 248 IgG responses with neutralization activity. Of note, the formation of cluster 1 was primarily 249 driven by gB-elicited immune responses following vaccination, while cluster 2 was primarily 250 driven by binding and neutralization against non-gB CMV glycoprotein epitopes (Fig. S4A,B) .
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