Author: Ivan Mercurio; Vincenzo Tragni; Francesco Busco; Anna De Grassi; Ciro Leonardo Pierri
Title: Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodies Document date: 2020_4_18
ID: mswmkgl4_27
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.17.046185 doi: bioRxiv preprint For modeling main interactions occurring between SARS-CoV-2 spike proteins and ACE2, thanks to the high percentage of identical residues shared by spike RBD from several CoV strains (Fig. 3) , it was possible to structurally align three objects consisting of the human ACE2-SARS-CoV-1 spike-RBD protein compl.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.17.046185 doi: bioRxiv preprint For modeling main interactions occurring between SARS-CoV-2 spike proteins and ACE2, thanks to the high percentage of identical residues shared by spike RBD from several CoV strains (Fig. 3) , it was possible to structurally align three objects consisting of the human ACE2-SARS-CoV-1 spike-RBD protein complex (2ajf.pdb) to the human ACE2-SARS-CoV-2 spike-RBD protein complex (6vw1.pdb, 6lzg.pdb) and the SARS-CoV-2 spike protein trimer (6vsb.pdb; 6vxx.pdb; 6vyb.pdb).
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