Selected article for: "activation pathogen recognition and immune response"
Author: Bourdon, Marie; Manet, Caroline; Montagutelli, Xavier
Title: Host genetic susceptibility to viral infections: the role of type I interferon induction
  • Cord-id: nsnvo3j6
  • Document date: 2020_11_20
    • ID: nsnvo3j6
    Snippet: The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies have shown that defective type I IFNs induction may hamper the ability to control vi
    Document: The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies have shown that defective type I IFNs induction may hamper the ability to control viral infections. In humans, moderate to high-effect variants have been identified in individuals with particularly severe complications following viral infection. In mice, functional studies using knock-out alleles have revealed the specific role of most genes of the IFN pathway. Here, we review the role of the molecular partners of the type I IFNs induction pathway and their implication in the control of viral infections and of their complications.

    Search related documents:
    Co phrase search for related documents
    • activation cascade and adaptive immunity: 1, 2, 3
    • activation dendritic cell and acute sars cov respiratory syndrome coronavirus: 1
    • activation dendritic cell and adaptive immunity: 1, 2, 3, 4
    • activation phosphorylation and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • activation phosphorylation and adaptive immunity: 1
    • activation phosphorylation and adaptor protein: 1, 2, 3, 4
    • activation phosphorylation and adaptor signal: 1, 2
    • activator signal transducer and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • activator signal transducer and adaptive immunity: 1, 2
    • acute sars cov respiratory syndrome coronavirus and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68
    • acute sars cov respiratory syndrome coronavirus and adaptor protein: 1, 2, 3, 4
    • acute sars cov respiratory syndrome coronavirus and lung viral load: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27
    • adaptive immunity and lung viral load: 1