Author: Barabutis, Nektarios
Title: Unfolded Protein Response in the COVID-19 Context Cord-id: k9qdju0q Document date: 2020_10_19
ID: k9qdju0q
Snippet: The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggest that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2 - inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairi
Document: The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggest that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2 - inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairing the destructed lung endothelium of the COVID-19 patients, may deliver a promising therapeutic possibility for those subjected to the devastating outcomes of the ongoing pandemic.
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