Author: MartÃn-Vicente, MarÃa; Medrano, Luz M.; Resino, Salvador; GarcÃa-Sastre, Adolfo; MartÃnez, Isidoro
Title: TRIM25 in the Regulation of the Antiviral Innate Immunity Cord-id: rq78nbpt Document date: 2017_9_22
ID: rq78nbpt
Snippet: TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the
Document: TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the melanoma differentiation-associated protein 5–mitochondrial antiviral signaling protein–TRAF6 antiviral axis and modulation of p53 levels and activity. In addition, the ability of TRIM25 to bind RNA may uncover new mechanisms by which this molecule regulates intracellular signaling and/or RNA virus replication.
Search related documents:
Co phrase search for related documents- activation ubiquitination and adaptive immune response: 1
- activation ubiquitination and adaptor protein: 1
- activator activation and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4
- activator activation and adaptive immune response: 1, 2
- activator activation and adaptor protein: 1
- activator activation and lung cancer: 1
- active rig and adaptor protein: 1
- active site and acute sars cov respiratory syndrome coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- active site and additional mechanism: 1
- active site and additional role: 1
- active site and lung cancer: 1
- active site and lysine residue: 1, 2
- active site cysteine and acute sars cov respiratory syndrome coronavirus: 1, 2, 3
- active site cysteine and lysine residue: 1
- acute sars cov respiratory syndrome coronavirus and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute sars cov respiratory syndrome coronavirus and adaptor protein: 1, 2, 3, 4
- acute sars cov respiratory syndrome coronavirus and additional mechanism: 1, 2, 3, 4, 5
- acute sars cov respiratory syndrome coronavirus and additional role: 1, 2, 3, 4, 5, 6, 7, 8
- acute sars cov respiratory syndrome coronavirus and lung cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date